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Posted: Wednesday, December 27, 2017 2:46 PM

Req ID:12222
Shift: Days
Employment Status:AF : Active : Regular : Full Time
Job Summary 13;
The Childrens Hospital of Philadelphia Research Institute is an interdisciplinary institution dedicated to conducting basic, clinical and translational research on conditions and diseases that affect children, and is part of The Childrens Hospital of Philadelphia and University of Pennsylvania research community.

The Bioinformatics Scientist position is in the laboratory of Dr. Dimitri Monos, Director of the Immunogenetics Laboratory in the Division of Genomic Diagnostics of the Department of Pathology and Laboratory Medicine.

The labs research focuses on the role of Histocompatibility (HLA) molecules and of the Major Histocompatibility Complex (MHC) in autoimmunity and transplantation. We are interested in the detailed characterization of the MHC by high throughput DNA sequencing technologies and the identification of polymorphisms important for many HLA:associated diseases and rejection processes in transplantation. The lab is supported by institutional, NIH and other Foundations grants.

To learn more about the CHOP Research Institute, Dr. Dimitri Monos and the research programs visit:
Interested individuals should send a cover letter, CV and must also complete a profile on our website at chopcareers. References and/or letters of recommendation will be requested.
Required Education and Experience 13;

o Ph.D. in bioinformatics, computational biology, computer science, mathematics, engineering or related discipline; or MS with at least three years of related experience
o Experience with experimental design, analysis, and interpretation of large multivariate datasets generated from a variety of platforms, such as SNP microarray, expression microarray, NGS, and single molecule sequencing platforms (PacBIO and Oxford Nanopore MinION)
o Demonstrated skills utilizing bioinformatics algorithms, tools and resources, e.g. sequence retrieval, alignment and clustering techniques, expression profiling and protein related analysis, using major databases and data standards in the field.
o Ability to design, develop, validate and maintain computational tools and algorithms for the analysis and interpretation of NGS data
o Experience working with UNIX/LINUX in a high performance computing environment
o Fluency in C++/JAVA, PERL/Python, R/Matlab, or other programming languages
o Strong working knowledge or training in advanced biomedical research (Background in Immunology, Histocompatibility, Immunogenetics, and/or HLA experience preferred)
o Experience with manuscript and grant preparation is preferred
o Ability to work collaboratively in a dynamic research environment
o Effective critical thinking and problem solving skills
o Excellent interpersonal skills to interact and communicate with both clinical lab technical staff and research staff
o Excellent writing, communication, and analytical skills
o Ability to work independently with minimal guidance while consistently exercising good judgment
o Ability to learn new technologies quickly
o Ability to work efficiently on multiple projects
Preferred Education, Experience and Cert/Lic 13;
Familiarity with next:generation sequencing and analysis is preferred. The successful applicant will become part of a highly interactive team that uses molecular biology, statistical genetics and bioinformatics to study the intricacies of the MHC. Postdoc/scientist will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. The postdoc/scientist will also be expected to acquire technical, lab management, and manuscript/grant writing skills and will also participate in seminars, lectures, poster sessions and presentations at national meetings.
The acquired experience will serve to extend, refine and enh


• Location: South Jersey

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